If the answer is no, consider a slight increase in dose (titration) or a change in timing before abandoning the compound
The body has to contend with increased oxidative stress, weakening immunity, and more DNA repair demands as we age
For steady maintenance, many book Refresh monthly or quarterly
Recommended maintenance doses are 5 mg, 10 mg, or 15 mg once weekly, and 15 mg is the maximum
(C) IH growth to adjacent cells was significantly reduced (Students t-test p0.05) in gtr1 strains compared to WT at 48 hpi
The primary antibodies employed were: P53 (Proteintech, 60283-2-Ig), pSer46-P53 (CST, 2521), FOXO4 (Proteintech, 21535-1-AP), P21 (CST, 2947), P16 (CST, 18769), BAX (CST, 2772), BCL2 (CST, 3498), Ki-67 (Proteintech, 84192-4-RR), Lamin B (CST, 13435), Cleaved Caspase 3 (CST, 9664), -H2AX (Abcam, ab81299), and GAPDH (Abcam, ab8245) as an internal reference for normalizing protein expression levels