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Similar content being viewed by others Introduction Obesity is a major chronic disease that continues to increase in prevalence worldwide and constitutes a key risk factor for development and progression of numerous related diseases including hypertension, dyslipidaemia and type 2 diabetes 1

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The cryo-EM structures of retatrutide-bound GLP-1R, GIPR and GCGR reveal a combination of conserved peptidereceptor interactions and receptor-specific conformations, particularly in ECL1, that enables retatrutide to execute agonism at multiple receptors

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