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This accumulation of reactive oxygen species (ROS) disrupts meiotic spindle assembly, impairs spindle assembly checkpoint signaling, compromises chromatin cohesion, and ultimately deteriorates oocyte quality and developmental potential in women of advanced reproductive age ( At the molecular level, several antioxidant interventions exert their protective effects through the activation of key cellular defense pathways as shown in Figure 3

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But dosing decisions are medical

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One particular group has been investigating metformin as a potential therapeutic intervention to reduce hepatotoxicity after APAP exposure

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