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The agency also issued multiple waves of warning letters (dozens in total) to telehealth companies, citing false or misleading claims that suggested compounded products were equivalent to FDA-approved drugs in safety, efficacy, or quality.

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Studies have shown that inhibiting VEGF-dependent angiogenesis in the TME with axitinib can relieve T cell hypoxia and limit the exposure of tumor-infiltrating T cells to metabolic stress, significantly improving the efficacy of immunotherapy