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Effect of sitagliptin plus metformin on beta-cell function, islet integrity and islet gene expression in Zucker diabetic fatty rats

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You are treating a biological system that could be 35 or 65

We are pleased to see the clinically meaningful weight loss in people treated with our oral GLP-1 therapy CT-996, which could eventually help patients address both chronic weight management and glycemic control indications, said Levi Garraway, MD, PhD, Roches CMO and head of global product development

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Most cases can be successfully managed without discontinuing treatment, allowing patients to continue benefiting from the medication's weight-loss effects