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Meis, S., Munsch, T., Sosulina, L

The 5-LOX enzyme, found in CD163 + tumor-associated macrophages, promotes the formation of hepatocellular carcinoma (HCC) by generating leukotrienes that augment cancer cell proliferation and stem cell capabilities [275]

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[42] found that IGF-1 promoted the senescence of rat articular chondrocytes by activating senescence-associated -galactosidase (SA--gal) and up-regulating p53 and p21 expression levels