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They should not be used by individuals with type 1 diabetes, during pregnancy or whilst breastfeeding, or by those with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) a hereditary condition associated with tumours of the endocrine glands

[8] [9] Additionally, GLP-1 suppresses glucagon secretion from pancreatic alpha cells, which helps prevent excessive glucose production by the liver

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Researchers may test retatrutide dosage for special populations once the medication is FDA-approved and available in the market

With all that said, the FDA's main concern is that anyone who is compounding or helping out with the national shortage should be using the exact form in the FDA approved commercial products, the Semaglutide base