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Zhang et al., Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering MiR-30b-3p

These short peptides regulate key processes such as cell migration, proliferation, and differentiation, while also modulating inflammation, promoting angiogenesis, and facilitating extracellular matrix (ECM) remodeling

This combination therapy provides a similar glycemic control as compared with intensive insulin regimen, associated with lower risk of hypoglycemia and weight gain [17]

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Future studies should explore alternative fixed ratios to define the most favourable balance between efficacy, safety, and tolerability