Through transcriptional and metabolic reprogramming, LAT1 plays a crucial role in maintaining intracellular amino acid levels in response to KRAS activation
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Hashimotos thyroiditis is an idiopathic thyroid atrophy due to a chronic autoimmune inflammatory reaction, being the most common form of hypothyroidism in humans ( Animal models have shown that the experimental induction of hypothyroidism leads to an involution of the spleen and lymph nodes as well as a decrease in the humoral and cell-mediated immune response ( Considering that hypothyroidism leads to immune system dysfunctions, and that ACE2 is expressed in thyroid gland, one could speculate that hypothyroidism might impact the outcomes in COVID-19 patients
Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, et al