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Pyroptosis-mediator GSDMD promotes Parkinson's disease pathology via microglial activation and dopaminergic neuronal death

Archived (PDF) from the original on 8 August 2016

Given that active demethylation occurs on numerous neighboring CGs, as shown during electro-convulsive treatment-induced neurogenesis in adult hippocampus (Ma et al., 2009b), the removal of their methylation through the repair machinery would involve extensive damage to DNA and thus might represent a costly mechanism (Szyf, 2009)

Its main benefit is that it reacts with cyanide (CN), nitric oxide (NO), and nitrous oxide (N2O), and is therefore often used as an antidote for toxicity

Principal component analysis (PCA), an unsupervised multivariate analysis, was used to discover general trends toward metabolomics data

Thats because treating neuroinflammation is more complicated and requires a different approach