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They help us locate genes associated with the disease, and sometimes play a more significant role by directly affecting a genes function. 1 Other common types of genetic disorders caused by the mutation of a single gene include: Cystic fibrosis Sickle cell anaemia Tay-sachs disease Phenylketonuria Colour-blindness How would I know if I had a MTHFR mutation or problem with the methylation cycle

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