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These conditions include: Stomach ulcers - Very high doses of B3 (niacin) could elevate the risk for ulcers or exacerbate existing ones

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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

Because of its unclear regulatory status, athletes should weigh the benefits against potential risks and test failures especially when preparing for competitions or under a physician-monitored plan

Research has also examined the compounds stability and formulation requirements