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13 In addition to being recommended in patients with ASCVD, GLP-1 receptor agonists are recommended for consideration as an add-on to metformin in patients without established ASCVD in whom there is a compelling need to minimize hypoglycemia, minimize weight gain, or promote weight loss

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An analysis of 26 studies (total 3020 patients) including 5 studies with psychiatric symptoms assessed as primary outcomes (for example, substance use disorders), and 21 studies with secondary outcomes, as well as an additional 10 registered clinical studies, was performed

doi: 10.1182/blood-2014-09-598656