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Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output

Factors like dosage or the severity of the wound might influence how quickly effects become apparent

At very high concentrations, some insulin receptor activity is noted but this is generally not relevant in standard research protocols

Tanzilli G, Truscelli G, Arrivi A, et al

Typically, bone broth is used in hot soups and stews, but you can get more adventurous than that