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This is not a flaw unique to Brello, but it is a tradeoff of the lower-cost, lighter-touch model

Initiate with the 2.5-mg dose once weekly After 4 weeks on the 2.5-mg dose, increase to the 5-mg dose once weekly If additional glycemic control is needed, you can continue to increase the dose by 2.5-mg increments after at least 4 weeks on the current dose

Chronic GCGR activation should increase plasma glucose levels and insulin levels would then need to rise to promote normoglycaemia during tri-agonist treatment, but this is not the case

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