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1 Heart rate and irregular heartbeats Retatrutides effects on the heart are part of its safety profile that clinicians and regulators are watching most closely.1,2 Theyre also one of the main reasons regulators want full long-term data before the drug is widely used

In 2025, the company delivered a solid +8.56% YoY revenue growth, driven by its immunology portfolio: Skyrizi ($17.56B) continues to surge with strong uptake across psoriasis and IBD, Rinvoq ($8.3B) is expanding rapidly across multiple inflammatory conditions, while Humira ($4.54B) continues to decline following loss of exclusivity marking a clear shift toward newer growth assets

Clin Interv Aging (2015) 10:54960

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The slowed gastric emptying, potential nausea, vomiting, and diarrhea all deplete fluids