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He C, Hart PC, Germain D, Bonini MG (2016) SOD2 and the mitochondrial UPR: partners regulating cellular phenotypic transitions

Some people are more sensitive to medications, so a sudden jump to a higher dose may cause problems

The process is simple but demands attention to detail

Although current data support the notion that HDACi overcomes resistance through epigenetic regulation and inhibition of pro-survival pathways, the limitations of small sample sizes and non-randomized designs necessitate validation through larger-scale studies (102)

Plant Mol Biol 49(5):429438

However, it's a stark reminder that things are only going to get hotter, with the Met Office warning about extreme weather which could reach 46 degrees in the future, causing most of us Brits to actually melt.