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These side effects are typically rare, and only seen in patients using a dose that is unusually high

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Given the initial improvement, we gradually stopped insulin therapy and increased metformin dose to 2 g per day, together with a hypocaloric diet after consultations with dietitians and 10 hours per week of physical activity

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(2022) Interplay of ZnONPs and/or SeNPs induces arsenic tolerance in soybean by regulation of antioxidants pool, WRKY genes, and expression of arsenic transporters