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12 , e2412558 (2025)

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Accumulating evidence shows that inhibitors of glutamine metabolism, such as V-9302, JHU-083, and CB-839, elicit stronger antitumor effects when used in combination with immune checkpoint inhibitors 144,145,146 (Fig

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Subjective evaluations Skin whitening and smoothening at the test site and improvement in fine lines were evaluated subjectively by the investigator and by the subjects in accordance with the following scoring pattern: 3= marked deterioration 2= moderate, visibly uneven deterioration 1= slight deterioration = no perceptible change or improvement = slight change or improvement = moderate change or improvement (whitening