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References Rhee SG, Kang SW, Jeong W, Chang TS, Yang KS, Woo HA

Sarkar R, Bansal S, Garg VK

Indoxyl sulfate, a uremic toxin, stimulates reactive oxygen species production and erythrocyte cell death supposedly by an organic anion transporter 2 (OAT2) and NADPH oxidase activity-dependent pathways

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Factors such as perinatal maternal stress, mode of delivery, environmental exposures, and genetic factors significantly influence the composition of the offsprings gut microbiota and can alter behavior and Central nervous system (CNS) structure (4150)

This happens through the aptly named "glutathione-ascorbic acid cycle." In another observational study, individuals with lower levels of vitamin C also had insufficient levels of glutathione, hinting at the symbiotic connection between the two