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doi: 10.3389/fendo.2024.1340625 Received 18 November 2023 Accepted 19 February 2024 Published 12 March 2024 Volume 15 - 2024 Edited by Changjun Li, Central South University, China Reviewed by Qiaoyue Guo, University of Maryland, Baltimore, United States Bo Gao, Air Force Military Medical University, China Updates Copyright 2024 He, Liu, Lin, Ding, Shao and Xiong

The amino acid sequence and specific modifications in its chemical structure determine its ability to selectively stimulate the release of growth hormone, while avoiding some adverse reactions that traditional drugs may cause, such as increased appetite, elevated prolactin, and elevated cortisol

Keywords: trimethylamine N-oxide, inflammatory bowel disease, gut microbiota, metabolites, immunometabolism 1

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This approach aims to reduce cost and improve the yield and purity of the produced peptides compared to traditional chemical synthesis methods alone

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