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Regarding meals, avoiding large portions close to bedtime and allowing at least three hours between the last meal and sleep can reduce gastrointestinal discomfort that might disturb rest

Discuss your individual risk factors, particularly if you're experiencing significant gastrointestinal symptoms, are in an early dose-escalation phase, or have pre-existing gastroparesis

For instance, it is now known that GR dimerization and DNA binding are both needed for full transrepression of proinflammatory genes (45, 46)

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This effect is particularly helpful for people who struggle with emotional eating or frequent hunger, as it reduces the urge to eat for reasons beyond actual physical need