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What about quinine, perhaps the best-studied bitter substance in human history

Bile Acid Malabsorption and GLP-1 Therapy Safety Bile acid malabsorption (BAM) is a known side effect in some post-cholecystectomy patients, where unabsorbed bile acids reach the colon and cause diarrhea or loose stools

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Tolerance often improves when meals during dose increases are smaller and lower in fat, reducing nausea without sacrificing nutrition

Conversely, if side effects are intolerable, discussing dose reduction or alternative strategies is important rather than discontinuing treatment without guidance