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Key factors influencing whether weight loss injections may be appropriate include: Disease activity : Patients in stable remission may be better candidates than those experiencing active flares Location and extent of disease : Individuals with upper gastrointestinal or extensive small bowel involvement may face greater risks Presence of complications : Strictures, fistulas, or previous bowel resections may increase the risk of adverse effects Current medication regimen : While there are no known direct pharmacokinetic interactions with immunosuppressants or biologics, monitoring for overlapping gastrointestinal symptoms is important Nutritional status : Patients already experiencing malnutrition or deficiencies may not be suitable candidates NICE guidance on obesity management acknowledges that certain medical conditions require specialist input when considering pharmacological weight loss interventions

378 , e34 (2018)

10.3389/fendo.2023.1085799

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