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Reactivation of FMR1 by CRISPR/Cas9-mediated deletion of the expanded CGG-repeat of the fragile X chromosome

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Scharf, Tingjun Hou, Tianhua Zhou, Ming-Wei Wang, Yan Zhang URL: Published: Cell Research, 25 August 2021, volume 31, pages 11631175 This study reports four high-resolution structures of full-length melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein stimulated by different ligands, including the FDA-approved drug bremelanotide (Vyleesi)

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Detailed mechanisms of MSCs in improving chemotherapy-induced ovarian impairment are discussed in Sect