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2023;46:384-390 - adjusted HR 1.58 (1.27-1.95) at 1-3 years

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[1] [2] The medication appears to influence areas involved in appetite control, including the hypothalamus and brainstem, where GLP-1 receptors help regulate hunger signals and promote satiety after meals

These findings should be overseen with glutamate as the major excitatory neurotransmitter in the central nervous system (i.e., cognitive functions such as learning and memory in the brain [200], the precursor of major inhibitory neurotransmitter GABA) but excitotoxic neuronal death as a direct result of high concentrations [201], and tight physiologic range that should be maintained [59]

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