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The addition of B12 does not boost weight loss, but may help combat the side effects of semaglutide, such as lethargy and dizziness, by promoting metabolism and increasing the availability of usable energy

Cunha, A., Gaubert, A., Latxague, L

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Zhang P, Zhou C, Ren X, Jing Q, Gao Y, Yang C, et al

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This is because, upon heating, the compact native form of BSA becomes more flexible and reactive, exposing the Tyr and Trp residues from the hydrophobic core of BSA molecule to a more polar solvent environment 64,65