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It is crucial to stick to the recommended dosages to avoid potential side effects and guarantee maximum effectiveness
In a multicenter double-blind RCT, long-term oral BCAA supplementation significantly reduced the composite risk of death, liver transplantation, and disease progression in patients with advanced cirrhosis compared with lactalbumin or maltodextrin controls, with event-free survival significantly improved in the BCAA group ( At the highest level of evidence, a Cochrane systematic review and meta-analysis incorporating 16 RCTs (n = 827) confirmed that oral BCAA supplementation significantly reduced the risk of hepatic encephalopathy (risk ratio 0.73, 95% CI 0.610.88
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found that signal transducers and activators of transcription 3 (STAT3) promote MYC expression in tumor cells in AML, which in turn regulates the transcription of amino acid transporter SLC1A5, promotes Gln metabolism in AML cells, and oxidative phosphorylation (OXPHOS) of leukemia stem cells (LSCs)
