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Cuproptosis, a recently discovered form of programmed cell death, is triggered by the accumulation of copper ions and involves the binding of copper to lipoylated proteins in the tricarboxylic acid (TCA) cycle, leading to protein aggregation and cellular demise [11,12,13]

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Sacco RL, Anand K, Lee HS, Boden-Albala B, Stabler S, Allen R, Paik MC: Homocysteine and the risk of ischemic stroke in a triethnic cohort: the NOrthern MAnhattan Study

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Hence, it is well protected from UV rays, pollution, and other environmental factors that may lead to lightening of the skin