The evidence below is per-compound, plus the CagriSema (cagrilintide + semaglutide) Phase 3 data as the closest analog
Fontoura, J
The trial looked at the safety and effectiveness of tirzepatide in two scenarios: Continuing to take tirzepatide at the maximum tolerated dose (10 or 15 milligrams [mg], depending on the patient) after initial treatment on that dose Lowering the dose to 5 mg after initial treatment to maintain weight loss
References GLP-1 Receptor Agonists and Insulin Sensitivity in PCOS: A meta-analysis demonstrated that GLP-1 receptor agonists are more effective than metformin in improving insulin sensitivity and reducing body mass index (BMI) in women with PCOS
Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease
Sharma A, Ambrosy AP, DeVore AD, Margulies KB, McNulty SE, Mentz RJ, Hernandez AF, Michael Felker G, Cooper LB, Lala A