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Joint pain while taking tirzepatide may stem from several factors: Rapid Weight Loss Effects : When you lose significant weight quickly (as many do on GLP-1 medications), your body undergoes biomechanical changes that can temporarily stress your joints

Macroalbuminuria occurred less (2.2%) in exenatide group compared to placebo group (2.5%) [HR 0.87 (95% CI: 0.701.07)]

Phase 3 trials typically enroll thousands

When used in conjunction with a healthy diet and exercise plan, GLP-1 injections can significantly enhance your weight loss efforts

Avoiding chronic under-eating after appetite suppression

Therefore, it is generally not recommended in these populations