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doi: 10.3928/02793695-20211207-03 115 WiersingaWJRhodesAChengACPeacockSJPrescottHC

In a phase 2 substudy that included participants with hepatic fat content 10%, 48-week administration of GLP-3 resulted in a robust, dose-dependent reduction in liver fat

reported an L-carnitine-mediated improvement in glucose plasma levels, lipid profiles, and histological manifestation in patients with NASH 11

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Based on animal reproduction studies, there may be potential risks to the fetus from exposure to semaglutide during pregnancy

11-13 GLP-1 receptors are expressed in multiple tissues, therefore, GLP-1RAs have multiple mechanisms of action (Figure 2)