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Thus, there is an urgent need to identify a marker of structural damage to the kidney before functional impairment and the vicious cycle of inflammation, microcirculatory disturbances, and local ischemia are established (116)

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In the subsequent phase III STEP trials of semaglutide, 2.4 mg once weekly, carefully up-titrated over 20 weeks, average weight losses of up to 18% were achieved over 68 weeks in people with obesity (start weight 107 kg) [40]

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