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Huang X, Wu M, Lin J, Mou L, Zhang Y, Jiang J

Acute neuroinflammation is associated with elevated metabolites in the tryptophan-kynurenine pathway, nitric oxide pathway, neopterin and major lipids 56

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The transcriptional upregulation of Ppara and Ppargc1a observed here reflects glucagon-driven mitochondrial activation [49], while the downregulation of lipogenic genes ( Fasn , Scd2 ) may stem from GIP receptor activation in adipocytes, redirecting nutrient flux away from storage

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