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In regards to tyrosinase and Melan-A both have been reported to lose expression progressively in melanoma from clinical stages I to IV

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The escalation ladder commonly looks like this: weeks 1 through 4 at 2mg, weeks 5 through 8 at 4mg, weeks 9 through 12 at 6mg, then continuing at 6 to 8mg for researchers who tolerate the escalation well