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Funding Statement This work was supported by National Institutes of Health (NIH) grants R01-DK55758, R01-DK127274, R01-DK131537, R01-DK099110, P01-AG051459, and RC2-DK118620 to P.E.S

We performed phosphorylated STAT3 (p-STAT3) staining in the whole brain

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Best to consume 30 minutes before any physical activity Legal Disclaimer: Statements regarding dietary supplements have not been evaluated by the FDA

I may initiate tirzepatide at 2.5 mg or 5 mg weekly based on these factors

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for the treatment of metabolic disorders, have demonstrated promising neuroprotective properties through multiple mechanisms, including anti-inflammatory and antioxidation effects, as well as preservation of the bloodbrain barrier