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From there, the dose can be increased by 2.5mg every four weeks, up to a maximum of 15mg weekly

Prolonged use may lead to dyskinesia, and tolcapone poses a risk of hepatotoxicity, necessitating regular monitoring of liver function

This anti-inflammatory action is mediated through several signalling pathways, including the inhibition of the nuclear factor kappa B (NF-B) pathway, contributing to the reduction of liver inflammation associated with NAFLD

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Peri-articular muscle biopsies in OA demonstrate fiber-type atrophy (especially type II fast-twitch fibers), increased infiltration by adipocytes and macrophages, fibrosis, and mitochondrial abnormalities