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NrrF is essential for iron homeostasis, is expressed under iron-limiting conditions under the control of Fur and is known to inhibit the translation of sdhA and sdhC mRNAs, which encode subunits of succinate dehydrogenase complex, an iron-containing enzyme

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The second and third most abundant IGFBPs are IGFBP-2 (32 kDa) and IGBP-1 (28 kDa), which can also bind IGF-1 and IGF-2, and are thought to modulate IGF actions by competing with the IGF receptors

Nat Rev Mol Cell Biol (2021) 22(2):7595

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