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This immune privilege is attributed to their low expression of major histocompatibility complex class II molecules (MHC-II, specifically HLA-DR) and the absence of co-stimulatory molecules (CD80/CD86), supporting their capacity for immune evasion (Khoury et al., 2014)

It is involved in bone formation, macronutrient metabolism, and defense systems against free radicals [116] and plays a fundamental role in brain function and development [117]

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Therefore, alternative methods of inducing non-apoptosis present new possibilities for treating tumors

Prevention of glutathione deficiency can slow down these processes

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