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Specifically, GALNT14 is implicated in the EGFR/mTOR pathway, and the suppression of GALNT14 activity leads to a reduction in mTOR activity, resulting in decreased levels of SLC7A11 and GPX4, ultimately leading to the induction of ferroptosis

132 However, the D2/D3 receptor agonist pramipexole demonstrated significant reductions in both THI scores and perceived tinnitus loudness in a four-week randomized, double-blind, placebo-controlled trial in presbycusic patients

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doi: 10.1016/S0140-6736(18)32744-2

This guide breaks down every dose of both compounds, maps them against each other week by week, and shows you exactly what the clinical trial data says about outcomes at each level

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