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4.5.4 Methodological limitations and confounding factors in metabolomic biomarker interpretation While amino acid-derived metabolites show promise as DKD biomarkers, rigorous interpretation requires acknowledging substantial methodological limitations

Thus, AR dimerization utilized tunable surfaces that are important for interdomain allostery and were found to be particularly important to bind degenerate DNA sequences, providing an explanation for how AREs that deviate considerably from the optimal textbook sequence in CaP still lead to robust transcriptional outputs