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Escitalopram-induced subclinical hypothyroidism

10.1056/NEJMoa1612917 41 HusainM.BirkenfeldA

Based on Phase 2 trial protocols, the standard approach looks like this: Weeks 1 to 4: 1 mg once weekly Weeks 5 to 8: 2 mg once weekly Weeks 9 to 12: 4 mg once weekly Weeks 13 to 16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (if tolerated) That is a minimum 16 to 20 week ramp-up to reach the maximum dose, compared to a similar timeline for Ozempic

Its systemic distribution and versatility are why it is often studied as a complement to more locally acting compounds