Repeated systemic dosing challenges that balance, raising copper-overload concerns and making the compound conceptually contraindicated in Wilsons disease and other copper-metabolism disorders
Because free radical damage is at the heart of all cellular ageing and chronic disease, insufficient glutathione can be connected with all kinds of ill-health
Gradual Return of Skin Pigmentation One of the most noticeable effects of stopping glutathione is the gradual return of your natural skin pigmentation
In endothelial cells (ECs), copper overload disrupts mitochondrial dynamics, increases fission and ROS production, and ultimately leads to cell death [34] In cardiomyocytes, copper promotes hypertrophy and inflammation [35], disrupts fatty acid and lipid metabolism, upregulates autophagy-associated proteins and genes, and impedes calcium ion uptake by the sarcoplasmic reticulum, thereby inhibiting myocardial contractility [36]
FEBS Lett 2000
Piaggi S, Raggi C, Corti A et al (2010) Glutathione transferase omega 1-1 (GSTO1-1) plays an anti-apoptotic role in cell resistance to cisplatin toxicity
