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Trials in HIV patietns have reported significant increases in muscle density and size [26]

Although the role of PGC1 in mitochondrial capacity (9) and overall mitochondrial protein quality (10) is well established, its effects on age-related sarcopenia and weakness are still debated, and study results are conflicting

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Gonzalez-Flores JN, Gupta N, DeMong LW, Copeland PR