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Using sterile water in a multi-dose vial creates a contamination risk once the stopper is punctured

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Dosing changes often depend on lab results, changes in body composition, or specific treatment targets

Johns Wort can accelerate clearance and diminish efficacy, whereas inhibitors like ketoconazole, clarithromycin, certain protease inhibitors, or excessive grapefruit intake may elevate serum estradiol and increase adverse-event risk

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Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability