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In addition, melatonin down-regulates pro-inflammatory mediators and thus acts protectively in liver cancer

Mechanistic investigations revealed OBBs dual regulatory capacity: (i) AMPK hyperphosphorylation-mediated bioenergetic enhancement through UCP1 upregulation, and (ii) inflammation resolution via inhibiting aberrant phosphorylation of IRS-1 coupled with coordinated modulation of immunometabolic signalingsuppressing proinflammatory mediators (MCP-1, CD68, Nos2, CD11c) while activating the downstream protein expression and phosphorylation (PI3K, p-Akt/Akt and p-GSK-3/GSK-3) [215]

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10.1038/s44161-022-00083-z 46 HeL.ZhangH

Its rich in healthy omega-3 fats Fatty fish used in sushi provide omega-3s like EPA and DHA, which help fight inflammation, support heart health, and may even improve body composition

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