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The accumulation of misfolded proteins leads to severe ER stress (ERS), which activates the unfolded protein response (UPR) (Oakes and Papa, 2015)

In fact, clinical studies indicate that low sperm glutathione leads to poor overall sperm health, manifested as improperly packaged DNA that is prone to fragmentation

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Free Radic Biol Med 52:185464

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Innovations such as next-generation ASO chemistries (cEt-containing ASOs) have significantly enhanced efficacy, particularly in difficult-to-access tissues, and provide safety benefits by eliminating the necessity for nanoparticle delivery