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While both approaches can help you shed pounds, research shows that GLP-1 medications typically produce more significant weight loss in the short term often 15-20% of body weight compared to 5-10% with diet alone but the most effective long-term strategy combines medication with sustainable lifestyle changes, as neither approach works optimally in isolation

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People with chronic migraine often end up in the emergency room or they need to try several preventive medications before finding one that can work for them, researcher Dr