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A recurring theme across non-incretin metabolic peptides is that early development efforts were constrained by pleiotropy, cardiovascular effects, or incomplete receptor characterization rather than by lack of metabolic relevance

Peer review Peer review information Nature Medicine thanks Naveed Sattar and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake

Taken together, these findings suggest that vitamin D exerts renal protection in CKD not only through inflammation, oxidative stress, and fibrosis regulation but also via its roles in autophagy, Klotho signaling, and podocyte stability, highlighting its broader therapeutic potential (Figure 3)

Glutathione is a naturally occurring compound found in nearly every cell of the body and plays an important role in maintaining cellular balance

This discovery explains why the cyclones lie where they do and the different numbers at each pole