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Since the liver has an abundant vascular structure and peripheral lymph distribution, ICC is prone to intrahepatic and extrahepatic metastases, and distant metastasis occurs in 70% of clinical autopsies ( Radical surgical resection is currently the only possible curative method for ICC, with a 5-year survival rate of about 30% and a 5-year recurrence rate of 60%70% ( Conclusions ICC with rectal metastasis is a rare mode of distant metastasis that may pose a diagnostic challenge

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[1] [3] If take-back programs are unavailable, follow FDA guidance for sharps disposal: Use an FDA-cleared sharps disposal container if possible If unavailable, use a heavy-duty plastic household container with a tight-fitting, puncture-resistant lid Label the container "SHARPS - DO NOT RECYCLE" When nearly full, follow local community guidelines for proper disposal Never place loose sharps in household or public trash cans Do not flush tirzepatide pens down the toilet To prevent future medication expiration, implement a system to track expiration dates when you receive new prescriptions